Sixx:A.M. is a hard rock band from Los Angeles, California, formed in 2007 by Mötley Crüe bassist, Nikki Sixx, DJ Ashba (Guns N' Roses), and James Michael. The group is best known for their song "Life Is Beautiful". The band released The Heroin Diaries Soundtrack in 2007, which is based upon Sixx's autobiography, The Heroin Diaries. They released their sophomore effort This Is Gonna Hurt based off of Nikki's second autobiographical book of the same name on May 3, 2011.

On December 5, 2011, lead singer James Michael announced the band would be releasing an acoustic EP entitled 7 on December 13, 2011, featuring seven new acoustic renditions of songs from the band's previous two studio albums. Michael also hinted at an upcoming surprise release from the band.

On July 18, 2013, they released a song called "Relief"' for their third album.

On January 14, 2014, the band announced via its Facebook page that the final song on the next album would be titled "Let it Haunt You (So Beautiful)." On July 31, 2014, the band announced that the title for their third album would be Modern Vintage. It was released on October 7, 2014.

In July 2015, Sixx stated that Sixx:A.M. planned to release two new albums and do a worldwide tour in 2016. Also in 2015, Ashba left his other band, Guns N' Roses, to focus solely on Sixx:A.M.

On March 1, 2016 Sixx:A.M released a single called "Rise," the details of the first of their two newly recorded albums, Prayers for the Damned, and dates for a new US tour scheduled to take place during April and May 2016. "Rise" debuted live in an acoustic format with no PA at an invite-only session at the Sanctum Soho Hotel in London, England on February 23 ("Stars" from the Modern Vintage album and "Life Is Beautiful" from The Heroin Diaries Soundtrack were also played). Pre-orders for the album started on March 4, and the album was released on April 29. The second of the two albums is, Prayers for the Blessed, Vol. 2, was released on November 18.

In October 2017, Sixx:A.M. released a tenth anniversary edition of their debut album The Heroin Diaries Soundtrack to commemorate its tenth anniversary and Nikki Sixx's biography of the same name. The re-release additionally contained three re-imagined tracks, including the songs "Life Is Beautiful, "Accidents Can Happen", and "Girl With Golden Eyes".

In March 2019, Sixx announced the band had recorded four new songs and also announced that they will release a greatest hits album. By September they released their first song in three years, "Talk to Me", in support of the #TalktoMe campaign against opioid addiction.

On August 22, 2020, the band returned with a remix of "Maybe It's Time", featuring various guest artists, for Artists for Recovery, a global recovery initiative. The song is also included on the Sno Babies soundtrack. On August 27, 2021, the band announced their greatest hits album entitled Hits, which would include a radio mix of "Talk to Me" and three unheard songs, along with remixes of two of their past album tracks. It was released on October 22, 2021.

Current members James Michael – lead vocals, rhythm guitar, keyboards, programming, piano (2007–2021); drums (2007–2011) DJ Ashba – lead guitar, backing vocals (2007–2021) Nikki Sixx – bass guitar, backing vocals (2007–2021)